your cascade chemistry team

Our Team

Every employee in our team at Organic Consultants, Inc. is a highly-skilled chemist with at least eight years of experience at our laboratories. Since 1980, our scientists have produced work for 21 US patents and four patent applications – all of which are held by our clients. This alone is testimony to the creativity and productivity of our people.
 

Jeremiah A. Marsden, PhD

President

Jeremiah A. Marsden, PhD-CASCADE Custom ChemistrySynthetic Organic Chemist specialized in heterocycle synthesis, catalyzed cross-couplings, conjugated aromatics, and steroids. Experienced with custom synthesis, scale-up, and route optimization. In September 2012 Jeremiah purchased Organic Consultants, Inc. when Lloyd Dolby retired.

After 8 years as a senior chemist at Organic Consultants, Inc., Jeremiah gained critical skills in synthesis particularly towards pharmaceutical processes. As the leader of Organic Consultants, Inc. since 2012, he manages the company’s team of chemists, communicates with clients and has increased the client base by over 300%, and still dedicates much of his time to synthetic work.

Jeremiah earned his PhD from the University of Oregon with Professor Michael Haley where his research involved the synthesis and characterization of phenylacetylene macrocycles and cross-coupling reactions. There he authored nine publications and one book chapter. Dr. Marsden received both a GAAN and IGERT fellowship while at the University of Oregon.
 

Alfred A. Avey, PhD

Senior Chemist

Alfred A. Avey, PhD-CASCADE Custom ChemistryDr. Avey obtained a Bachelor of Science degree in Chemistry from San Diego State University in 1987 where he conducted undergraduate research with Professor E. J. Grubbs. Following graduation, he worked as an analytical chemist for the City of Burbank, CA. In 1988 he began graduate studies at the University of Oregon and received his PhD in 1993 with Professor David R. Tyler. His graduate research was on the synthesis and reactivity of water-soluble organometallic compounds.

Following his PhD, Dr. Avey was a Postdoctoral Fellow with Professor Ross H. Hill at Simon Fraser University where he studied the synthesis and photochemistry of small molecules for the direct photolithographic depositing of metals and metal oxides.

Dr. Avey has worked at Organic Consultants, Inc. since 1996 focusing on the synthesis of morphinan derivatives and other alkaloids. Dr. Avey is co-inventor on several patents in this area and several more on the synthesis of other API’s.
 

Nick Janofsky

Director of Laboratories

nick janofsky cascade custom chemistryNick Janofsky earned a Bachelor of Arts Degree in Chemistry and Biology from Lawrence University in 2003. Since graduating, Nick has been employed as an analytical chemist and GMP manufacturing specialist working in the quality control of small molecule reagents, API and final dosage form pharmaceutical products. He has gained extensive chromatographic and spectroscopic method development experience working within GMP/GLP regulated environments where he has utilized a variety of techniques such as HPLC, GC, ICP, Uv and ELISA to develop analytical methods for final product assay, stability indicating impurity assay, trace residue analysis, reaction monitoring and assay of raw materials which meet USP <1225> and ICH Q2A method validation standards.

Nick has also participated in API manufacturing process development. As a project manager, it has been Nick’s responsibility to plan and coordinate the scale up of bench top synthetic process to kilo scale process with various project work groups. Working in this role, he has conducted engineering studies and authored documentation to support GMP manufacturing including equipment qualification protocols, process validation protocols, MMRs, batch records and process cleaning assessments.

Nick currently administers the quality control program at Organic Consultants ensuring regulatory compliance with agencies such as the FDA, DEA and EPA. In addition to quality management, Nick also collaborates with our PhD chemists to provide hands on analytical support for GMP regulated manufacturing.
 

Micah J. Bodner, PhD

Senior Chemist

micah j bodner phd cascade custom chemistryDr. Bodner earned a Bachelor of Science degree in Biochemistry from the University of Oregon in 2003 where he conducted undergraduate research in chemistry with Professor J. Keana. He earned a PhD in 2010 at the Johns Hopkins University where he worked with Professor C. A. Townsend developing new asymmetric syntheses of carbapenem antibiotics and elucidating the function of enzymes in the thienamycin biosynthetic pathway. This work resulted in four publications and a patent.

He returned to the University of Oregon for a postdoctoral research position in a collaboration between the labs of Professor Michael Haley and Andrew Berglund. His work synthesizing pentamidine derivatives for medicinal and mechanistic studies was funded by a Myotonic Dystrophy Foundation fellowship and a Ruth L. Kirschstein NRSA.

He became a member of Organic Consultants, Inc. in the fall of 2012.
 

Patrick Pinson, PhD

Senior Chemist

patrick pinson phd cascade custom chemistryDr. Pinson earned a Bachelor or Science degree in Chemistry at the University of California, Davis in 1995 where he worked elucidating the alkyne zipper reaction with Michael Nantz. He then was employed as a production chemist at Syva Co. (Syntex) in Cupertino, CA preparing therapeutic and drug of abuse analogs for diagnostic testing. In 2001, he obtained a PhD in organic chemistry, while studying with Charles Grissom, at the University of Utah in Salt Lake City. While in Utah, he prepared several Vitamin B12-chemotherapy drug conjugates and co-authored a paper.

Patrick then moved to Reykjavik, Iceland where he provided drug discovery services for Decode Genetics. He then moved to Oregon where his work in dye chemistry at Invitrogen (Molecular Probes) resulted in one patent and a publication.

He became a member of Organic Consultants, Inc. in the fall of 2013.
 

Laura Shirtcliff, PhD

Senior Chemist

laura shirtcliff phd cascade custom chemistryDr. Shirtcliff graduated from the University of California at Santa Cruz in 2001 with a B. S. in Biochemistry and Molecular biology, where she worked in the lab of Prof. Bakthan Singaram on boronic acid glucose sensors. She earned her PhD researching concerted heterocyclic cyclization reactions through a combination of synthesis, methodology and computational chemistry with Prof. Michael M. Haley. Her doctoral work resulted in 11 publications. Laura was then awarded an NSF-IFRP postdoctoral fellowship to conduct research at the ETH-Zurich, Switzerland under the advisement of Prof. François Diederich, where she published two papers on novel switchable organic nano-containers.

Following her time in Switzerland, in 2008, Laura accepted an academic position at Oklahoma State University. With the assistance of her students, she conducted research into the synthesis and photophysical properties of n- and p-type organic semiconductors.

Laura returned to her native state of Oregon as a senior scientist at Organic Consultants, Inc. in February of 2014.
 

Yariv Donde, PhD

Senior Chemist

Yariv Donde, PhD-CASCADE Custom ChemistryDr. Donde earned a B.S. degree in chemistry from California State University, Fullerton in 1991 where he conducted undergraduate research in synthetic methods with Professor Gene Hiegel. This work resulted in a publication. Dr. Donde went on to earn a Ph.D. in organic chemistry from the University of Wisconsin, Madison in 1996, where he worked with Professor Edwin Vedejs on the asymmetric synthesis of P-chiral phosphines . During his time at Wisconsin, Dr. Donde was awarded an Eastman Kodak graduate fellowship and was also co-author on two publications.

After graduate school, Dr. Donde returned to Southern California where he was an NIH postdoctoral fellow in the labs of Professor Larry Overman at the University of California, Irvine (1997-1999). At Irvine, he worked on the catalytic asymmetric synthesis of allylic amines by the rearrangement of allylic imidates using planar chiral palladium catalysts. This work resulted in two publications and a book chapter.

Dr. Donde joined Allergan, Inc. in 1999, where he worked as a medicinal chemist primarily in the area of prostaglandins for the treatment of glaucoma. During his 16 years at Allergan, Dr. Donde co-authored over 40 patents and 4 publications.

Dr. Donde joined Organic Consultants in July 2015.
 

Scott Mohler

Head of Business Development

scottMr. Mohler graduated from the University of Illinois Urbana-Champaign in 1995 with a B.S. in Chemistry, working on synthesis of molecular models of transmembrane protein signaling with Professor Peter A. Petillo. Upon graduation, he worked as a medicinal chemist and combinatorial chemist for P&G, Abbott Labs, and Searle/Pharmacia. After the Pfizer acquisition of Pharmacia, Scott became a project manager for a small API facility, managing clinical, validation & commercial projects. After helping to formalize & improve the internal processes, he took over the West Coast Business Development role.

Since then, Scott has found a niche in helping small drug discovery service organizations implement project management & sales processes, providing the stability required for responsible growth.

Scott joined Cascade in December 2015 as head of Business Development.
 

David Quincy

Senior Chemist

davidDavid has a M.S. from the Univeristy of Nebraska – Lincoln and a total of 35 years of laboratory experience in organic chemistry/medicinal chemistry research. He began his career in organic chemistry as an undergraduate research assistant with Nicholas Natale at the Univeristy of Idaho performing multi-step organic synthesis of 4-chloro-methyl-3,5-dimethyl-isoxazole and novel 1,4-dihydropyridine calcium channel blockers of the Nifedipine class. He learned peptide chemistry at Abbott Laboratories with Megumi Kawai who had post-doc’d with Gerald D. Fasman at Brandeis University, and then later with Dan Rich at the Univeristy of Wisconsin School of Pharmacy. While at Abbott Laboratories, David invented (discovered) hepta-peptide and hexa-peptide analogues of the C-terminus of the anaphylatoxin Complement C5a. Two patents resulted and were assigned to Megumi as the principal inventor. Upon returning to graduate school David pursued graduate studies in asymmetric organic catalysis via chiral bis-oxazoline metal chelate complexes for performing asymmetric room temperature Diels-Alder reactions. He created >10 novel chiral ligands and performed over 100 asymmetric room temperature Diels-Alder reactions. Upon completing a M.S. degree he returned to the pharmaceutical industry by joining the Eisai Research Institute and contributed to the development of anti-cancer drug Eribulin by performing the scale-up synthesis of multi-gram quantities of the C1-C13 fragment of the carbohydrate natural product Halichondrin B according to the methodology of Yoshito Kishi. He also had repeated experience in peptide based projects and organic chelator synthesis in the form of DTPA and DOTA metal chelator analogs. He also has experience with a start-up biotech company developing peptide and antibody conjugation and immobilization strategies and surface chemistry. He has 7 years of experience in the process/scale-up chemistry group at Elan Pharmaceuticals and participated in the process development and process optimization with 4 compounds that advanced to clinical trials. He participated in the technology transfer of two projects to CMOs and provided critical insight and guidance that resulted in further refinement of the manufacturing process of one of the projects that enabled successful manufacture of the compound on 200 kg scale. Before joining Cascade Custom Chemistry he was a member of the Organic Manufacturing group at Life Technologies/Thermo Fisher Scientific and was responsible for the synthesis of numerous fluorescent dyes and hetero-bifunctional crosslinkers. He also participated in synthetic method troubleshooting and has experience with ISO 9001 and ISO13485 manufacturing environments and some cGMP experience.
 

Mac Monson

Quality Assurance

mac monsonMac Monson earned a Bachelor of Science degree from the University of Oregon in 2008. As an undergraduate he conducted research in the laboratory of Dr. Michael Haley, synthesizing highly conjugated aromatic compounds with novel optical and electronic properties. After graduating, Mac worked for Asemblon, Inc. in Redmond, Washington, preparing straight chain alkane thiols for application in Self-Assembled Monolayers.

In 2011, Mac obtained his Master’s degree in Chemistry from the University of Southern California, where he studied fungal secondary metabolites for use in drug design with Dr. Clay Wang. After receiving his graduate degree, Mac was a Chemistry Instructor at Lane Community College in Eugene, Oregon for five years.

He became a member of Cascade Chemistry in March 2016.
 

Kevin McGee

Senior Chemist

Mr. McGee earned a Bachelor’s of Science degree in Chemistry from Michigan State University and embarked upon a career as an industrial chemist in 1997. Since that time, he has developed his skills and knowledge with increasing responsibility for API-CMC development at various biotech and pharmaceutical companies in the San Diego biotech cluster. Having worked on projects at all phases of development through commercial process validation, Mr. McGee has the knowledge required to design & develop a robust manufacturing process, API supply methodology, and all related API development activities including ancillary functions such as analytical and solid state property development while ensuring that intermediate goals and deliveries are met. These abilities are complimented by a full knowledge of the relevant ICH and CFR regulations and how to effectively implement those requirements, even having authored IND and NDA documents. After being on the customer side for many years, Mr. McGee is excited to bring this experience and understanding of the client’s needs to Cascade Custom Chemistry.
 

David C. Muchmore, PhD

On-Call Chemist

David C. Muchmore, PhD-CASCADE Custom ChemistryDr. Muchmore received a Bachelor of Science from Dartmouth, College and a PhD from the California Institute of Technology, where he studied synthetic organic chemistry with Professor Robert E. Ireland. He subsequently spent 13 years as a research associate in the laboratory of Professor F. W. Dahlquist at the University of Oregon. During this time, he worked on preparative methods, ranging from synthesizing small molecules for protein modification and for incorporation of stable isotopes into proteins to developing expression systems for those proteins. He then joined Bend Research and worked on enzymatic resolution and a variety of organic synthesis problems. Use of biological processes for these preparations was a major emphasis.

Dr. Muchmore was awarded a patent for methods of enzymatic resolution. He has been at Organic Consultants, Inc. for 16 years. More than twenty publications have resulted from this accumulated work.
 

Lloyd J. Dolby, PhD

Founder

Lloyd J. Dolby, PhD-CASCADE Custom ChemistryProfessor of Chemistry at the University of Oregon. He has a Bachelor of Science in Chemistry with High Honors from the University of Illinois where he did undergraduate research with Professor Kenneth Rinehart. Dr. Dolby’s PhD degree is from the University of California at Berkeley with Professor Donald Noyce. After a postdoctoral year at the University of Wisconsin with Professor Eugene van Tamelen, he began his academic career at the University of Oregon where he directed the studies of 22 PhDs, many of whom have led distinguished careers. This body of work resulted in nearly eighty publications ranging from secondary isotope effects to alkaloid synthesis.

Dr. Dolby’s honors and activities include a National Science Foundation Postdoctoral Fellowship, an Alfred P. Sloan Fellowship, and a NIH Career Development Award. He was a visiting Professor at the University of Tokyo and he consulted for the National Cancer Institute.

Dr. Dolby retired in September 2012 and sold the company to Dr. Marsden. Dolby passed away in May 16, 2014 due to complications from cancer.
 

Shervin Esfandiari, PhD

Retired Chemist & Consultant

Shervin Esfandiari, PhD-CASCADE Custom ChemistryDr. Shervin Esfandiari earned his Bachelor of Science and Master of Science degrees from the University of Tehran.  His PhD is from the University of Oregon with Professor Lloyd Dolby. His academic career began at Pars College where he rose to Dean of Chemistry. He then moved to The Free University of Iran where he became the Vice President of that university.

Dr. Esfandiari’s academic work resulted in four papers, two books and three educational films. He also began a chemical consulting business in Iran, and his work there resulted in several commercial applications. After returning to the United States 18 years ago, he joined Organic Consultants, Inc. His work here has contributed to two papers and nine patents.